Responsible Research with 1P-LSD
Always practice responsible research. You should read and educate yourself before undertaking research with any chemical. The Psychonaut Wiki has some very helpful resources and information on 1P-LSD, so does Set and Setting. Never conduct research with a chemical without learning about it first.
WARNING This product is not for human or veterinary use.
What is 1P-LSD?
1P-LSD is a novel psychedelic substance of the lysergamide class. 1P-LSD is closely related to LSD and is reported to produce near-identical effects. Due to its novelty, little is known about the pharmacology of 1P-LSD, but it is thought to produce its effects by binding to serotonin receptors in the brain.
1P-LSD is a semisynthetic compound of the lysergamide family. It is similar to LSD and is named for the propionyl group bound to the nitrogen of the polycyclic indole group of LSD. Propionyl consists of the carbonyl chain CH3CH2CO- bound to an amino group. 1P-LSD is homologous to ALD-52, which holds an acetyl group bound to the nitrogen instead of the propionyl group bound at the same location. The structure of 1P-LSD contains a polycyclic group featuring a bicyclic hexahydro indole bound to a bicyclic quinoline group. At carbon 8 of the quinoline, an N,N-diethyl carboxamide is bound.
Based on its structural similarity to LSD, 1P-LSD likely acts as a partial agonist at the 5-HT2A receptor. The psychedelic effects are thought to primarily come from its efficacy at the 5-HT2A receptors distributed throughout the brain. 1P-LSD also likely displays binding activity at a wide range of monoamine receptors, such as those for dopamine and norepinephrine. However, there is currently no data to support these claims.
It has been theorized that 1P-LSD may act as a prodrug for LSD. While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. Follow-up studies are currently being conducted to compare the affinity and selectivity of LSD and 1P-LSD at 5-HT receptors, and to determine whether 1P-LSD is hydrolyzed to LSD in vivo. Otherwise, it is possible that 1P-LSD may be capable of exerting its own psychedelic effect.
Some of the most commonly reported effects are:
- Physical euphoria
- Tactile enhancement
- Stamina enhancement
- Appetite suppression
- Bodily control enhancement
Potential Side Effects
- Difficulty urinating
- Excessive yawning
- Increased perspiration
- Muscle contractions
- Muscle spasms
- Pupil dilation
- Increased salivation
- Vasoconstriction – Vasoconstriction may lead to users feeling cold, especially in the extremities
1P-LSD is classified as illegal in:
- Czech Republic
- United Kingdom
This list is not exhaustive, so do your own research into the legal status in your country before ordering!
All products are strictly for research purposes only and not for human consumption.
Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20’c where possible