4-HO-MET

Chemistry

4-HO-MET, or 4-hydroxy-N-ethyl-N-methyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine chemical class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-HO-MET is substituted at R₄ of its indole heterocycle with a hydroxyl functional group OH−. It also contains a methyl group and an ethyl chain bound to the terminal amine R_N of its tryptamine backbone (MET).

4-HO-MET is a 4-hydroxy homolog of 4-Ac0-MET and the N-substituted ethyl homolog of psilocin (4-HO-DMT). It is also the 4-hydroxyl analog of the base tryptamine MET.

Pharmacology

Further information: Serotonergic psychedelic

4-HO-MET’s psychedelic effects are believed to come from its activity at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.

Disclaimer

4-HO-MET .FUMARATE is for research use – Not for human or veterinary diagnostic or therapeutic use. It is the responsibility of the purchaser to determine suitability for other applications.

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