3-HO-PCP, or 3-hydroxyphencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. The structure of 3-HO-PCP is comprised of cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring, substituted at R3 with a hydroxy group.
3-HO-PCP is a structural analog of PCO and a homolog 3-MeO-PCP.
Further information: NMDA receptor antagonist
Like other arylcyclohexylamine dissociative, 3-HO-PCP acts principally as an NMDA receptor antagonist
The NMDA (N-Methyl-D-Aspartate) receptor, a specific subtype of the glutamate receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord; for the signals to pass, the receptor must be open. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. This disruption of neural network activity causes network disintegration, some research suggests, by hyperconnectivity throughout the brain. This causes an increase in noise (random, nonsensical and erraneous data) on the cerebral network and thus produces loss of normal cognitive and affective processing, psychomotor functioning, anesthesia. This is often observed in those showing psychosis or induced with high-dose IV THC or Ketamine in healthy participants, please see references.
Unlike many other dissociatives, 3-HO-PCP has also been found to have appreciable affinity as a u-opioid receptor agonist in animal models. However, the extent to which this applies to humans remains unknown.
3-HO-PCP .LARGE CRYSTAL is for research use – Not for human or veterinary diagnostic or therapeutic use. It is the responsibility of the purchaser to determine suitability for other applications.