NM-2201

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NM-2201 (also known as CBL-2201) is an indole-based synthetic cannabinoid that presumably has similar properties to the closely related 5F-PB-22 and NNE1, which are both full agonists and unselectively bind to CB1 and CB2 receptors with low nanomolar affinity.

Pharmacology

NM-2201 acts as a full agonist with a binding affinity of 0.332 nM at CB1 and 0.732 nM at CB2 cannabinoid receptors. It has been linked to serious adverse events in users.

Legal status

NM-2201 is specifically banned in Sweden, Germany (Anlage II),[8] and Japan[9] but is also controlled in many other jurisdictions under analogue laws. On May 30, 2018 the United States Drug Enforcement Administration, Department of Justice published a notice of intent to place NM-2201 and 4 other synthetic cannabinoids in schedule I of the Controlled Substances Act. This notice went into effect on June 29, 2018

IUPAC name

Naphthalen-1-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate

CAS Number

837122-21-7

Formula

C24H22FNO2

Molar mass

375.443 g·mol−1

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