5-Chloro-αMT HCL


5-Chloro-α-methyltryptamine (5-Chloro-αMT), also known as PAL-542, is a tryptamine derivative related to α-methyltryptamine (αMT) and one of only a few known specific serotonin-dopamine releasing agents (SDRAs).It has been investigated in animals as a pot

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5-Chloro-α-methyltryptamine (5-Chloro-αMT), also known as PAL-542, is a tryptaminederivative related to α-methyltryptamine (αMT) and one of only a few known specific serotonin-dopamine releasing agents (SDRAs). It has been investigated in animals as a potential treatment for cocaine dependence. The EC50 values of 5-chloro-αMT in evoking the In vitrorelease of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) in rat synaptosmes were reported as 16 nM, 54 nM, and 3434 nM, with an NE/DA ratio of 63.6 and a DA/5-HT ratio of 3.38, indicating that it is a highly specific and well-balanced SDRA. However, 5-chloro-αMT has also been found to act as a potent full agonist of the 5-HT 2A receptor, with an EC value of 6.27 nM and an efficacy of 105%, and almost assuredly acts as a potent agonist of other serotonin receptors as well.


5-Chloro-αMT .HCL is for research use – Not for human or veterinary diagnostic or therapeutic use. It is the
responsibility of the purchaser to determine suitability for other applications.

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