25B-NBOH or 2C-B-NBOH, is a serotonergic N-benzyl derivative of the substituted phenethylamine psychedelic known as 2C-B. 25B-NBOH is a substituted phenethylamine with methoxy groups CH3O- attached to carbons R2 and R5 as well as an bromine atom attached to carbon R4. It differs from 2C-B structurally through a substitution on the amine (NH2) with a 2-hydroxybenzyl (BOH) group. 25B-NBOH shares this 2-hydroxybenzyl substitution with other chemicals of the NBOH family. This NBOH addition is comprised of a hydroxy ether OH- bound to a benzene ring at R2.
Further information: Serotonergic psychedelic
25B-NBOH has efficacy at the 5-HT2A receptor where it acts as a potent agonist.
This compound is pharmacologically unique when compared to other psychedelics due to the unusually high selectivity it displays for various serotonin receptors. It is notable as one of the most selective agonist ligands for the 5-HT2A receptor with a pEC50 value of 9.87 nM It has a pKi of 0.061 nM at the human 5HT2A receptor, similar to the better-known compound 25B-NBOMe.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
25B-NBOH .HCL is for research use – Not for human or veterinary diagnostic or therapeutic use. It is the responsibility of the purchaser to determine suitability for other applications.
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